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The logic: cagrilintide adds amylin satiety, so the same hunger control can sometimes be reached with a lower retatrutide dose, which may reduce dysesthesia and GI side effects

Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

Its cytoprotective effects in gastrointestinal tissue have been linked to interactions with prostaglandin and dopamine systems

Apr 2016;4(2):161-166

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