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doi:10.1177/0300060518786918

Last Updated: April 2023

J Toxicol Sci 32(5):453468 Zhu W, Fung PC (2000) The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl 4 -induced acute liver injury of mice

Here, elevated NO production as a result of increased activation of NOXs, in particular NOX4 leads to the stabilisation of HIF-1 and thus promotion of endothelial cell (EC) survival, migration, differentiation, and therefore neovascularisation 64,106,107,108