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7.2 episodes per 100 patient-years of exposure, respectively)

In our experience treating thousands of patients, small dose adjustments including holding at a lower dose longer or modifying escalation timing often determine whether someone tolerates therapy long enough to reach meaningful weight reduction

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Thats where one word started to matter: Perseverance

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The underlying biology has shifted, the body has begun to defend its new lower set point, and the medication's effect has been overlaid by an adaptive response that the medication does not, on its own, fully overcome