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Moreover, the SIRT3 inhibitor 3-TYP significantly increased mitochondrial ROS accumulation in UV-irradiated cells treated with caffeine (Figure 4D)

Clinical development of new drug-radiotherapy combinations

Even though PG is a benign tumor, treatment is required due to associated risk of ulceration and bleeding, cosmetic concerns, and the low likelihood of spontaneous regression

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Interactions between cells and collagen have been demonstrated to be crucial for regulating cell adhesion, proliferation, and differentiation [71]