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Results: The percent of individuals achieving the exposure target at the time of first PK collection was higher in subjects receiving initial doses provided by the model-informed precision dosing platform (cohort C, 75%) versus subjects receiving initial doses based on either of the two other approaches (conventional guidelines/cohort A, 25%

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In line with these earlier studies, a recent study with Han Chinese showed maternal inheritance of mtDNA variants in schizophrenia as evidenced by sequencing data of the entire mitochondrial genomes of probands from 11 families with a family history and maternal inheritance pattern of schizophrenia [112]

Some trials have shown promising benefits of supplementation with vitamin B12 on liver enzymes and metabolic markers, while others have called for larger studies to firmly establish these effects

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