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[DOI] [PubMed] [Google Scholar] Anwar K., Iqbal J., Hussain M.M

A potential role for the gut microbiome in substance use disorders

These multiprotein complexes play a pivotal role in orchestrating the inflammatory response by enabling caspase-1dependent activation of the potent pro-inflammatory cytokines interleukin-1 (IL-1) and interleukin-18 (IL-18) upon detection of cellular danger signals (233)

In light of these mixed findings, there is a need for further RCTs specifically assessing these outcomes with adequate follow up as these events may not occur soon after the start of therapy