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The occurrence of fatigue could be related to excessive immunity, depletion of branched chain amino acids and fatty acids, CNS toxicity accumulation caused by damage to olfactory sensory neurons, mitochondrial dysfunction, and oxidative stress (Zhou and Jiang, 2019)

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J Cell Sci 125:49634971

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This can be explained by a potential synergy between ISR (ATF4 signature) and OSR (NRF2 signature) in the liver (Fig