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In addition to the direct effects of altered glutamine consumption on the function of immune cells and glutamine metabolism in the TME, the functional changes in the tumor cells themselves also directly affects the anti-tumor response

Parkinsons disease and neurodegeneration: GABA-collapse hypothesis

Intestinal epithelial cells primarily degrade Trp via the kynurenine pathway, which is essential for regulating colonic inflammation and colorectal cancer [114]