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Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs

Metabolomic analyses have revealed higher concentrations of amino acids, especially glutamine, in CRC cells containing mutated KRAS than in wild-type CRC cells (162)

Glutathione Glutathione is often dubbed the master antioxidant due to its pivotal role in maintaining cellular health and combating oxidative stress, one of the key factors contributing to aging and many chronic diseases

Low levels of ROS can activate host cells in the tumor microenvironment, and promote glucose metabolism in tumors to maintain the high energy consumption of tumors by inducing mitochondrial autophagy, altering key enzymes and genes related glucose metabolism and activating signal pathways

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

This approach not only produces synergistic effects across these levels but also enhances drug delivery efficiency and mucosal retention through the use of natural polymeric materials, thereby comprehensively improving the efficacy of 5-ASA ( FIGURE 2 2.2 Combination of TCM formulations and 5-ASA: holistic multi-target regulation The combination of TCM formulations with 5-ASA demonstrates multidimensional synergistic advantages in clinical efficacy, mechanisms of action, and safety, significantly expanding the scope of disease management beyond conventional 5-ASA monotherapy