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Harada K, Hwang H, Wang X, Abdelhakeem A, Iwatsuki M, Murphy MAB, Maru DM, Weston B, Lee JH, Rogers JE, Trail A, Shanbhag N, Zhao M, Bhutani MS, Nguyen QN, Swisher SG , Ikoma N, Das P, Hofstetter WL, Badgwell BD, Ajani JA

Emodin can suppress cell growth through inducing cell cycle arrest at G0/G1, S and G2/M stages, such as G0/G1 arrest in NSCLC cells via hyaluronan synthase 2 (HAS2)-mediated signaling [461], and S and G2/M phases arrest in liver cancer (Hep G2) cells [456]

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Deficiency of zinc can lead to subsequent health issues

This supports topical efficacy on dermal structures, including fibroblasts

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