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The mucosal layer is a key component of the intestinal barrier system, and emerging therapies for its protection focus on a three-step strategy of thickeningaugmentationquality enhancement: First, orally administered ROS-responsive thiolated hyaluronic acid hydrogel (HASH) has been shown to form an artificial mucous-like layer at the lesion site [409], physically blocking pathogen invasion and remodeling the microbiota

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