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Emotional Symptoms High Anxiety Restless mind Cannot turn your brain off when you want to relax Disorganized attention or inability to focus Worry too much about things you should not Gets overwhelmed easily Depression OCD (Obsessive Compulsive Disorder) Physical Symptoms Behaviors that we typically associate with autism, such as: Complex Motor Sterotypies (CMS) looks like flapping or stimming Tics Migraines Seizures Symptoms of PANDAS/PANS Cannot handle folate supplements: Folates are made up of numerous glutamic acids conjugates

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Turning our focus to screens treated with SP3N, we identified a profound enrichment of the substrate receptor FBXO22 and other components of the SCF FBXO22 ligase complex in the FKBP12 HIGH population, again accompanied by components of the proteasome and COP9 signalosome, thus corroborating chemical competition experiments (Fig