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On the other hand, vitamin B12 deficiency aggravates the GI tracts health, creating a vicious cycle

doi: 10.30466/vrf.2019.76137.2015, 33

TGF- is known to be elevated in the aqueous humor in all types of glaucoma

Nat Med 8:901902 Peclat TR, Agorrody G, Colman L, Kashyap S, Zeidler JD, Chini CCS, Warner GM, Thompson KL, Dalvi P, Beckedorff F et al (2024) Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity