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doi:10.1016/j.fertnstert.2016.12.018

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Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes

To test whether E27 accounts for STAT2 downregulation, an RCMVE mutant lacking E27 was constructed by CRISPR/Cas9mediated mutagenesis resulting in an E27deficient RCMVE (E27)