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Although studies have shown that Nrf2 and Nrf2-activating chemicals have opposing effects on the NLRP3 inflammasome that are not dependent on Nrf2-mediated gene expression, both effects are independent of the transcriptional activity of Nrf2 [129]

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259 Importantly, DHEA may be contraindicated in women with PCOS, who generally have elevated levels of androgens, including DHEA-S

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