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Excitotoxicity in neurodegenerative diseases Neurodegeneration, characterized by progressive neuronal loss, drives incurable disorders like AD, PD, HD, and amyotrophic lateral sclerosis (ALS) [60, 138]

A common strategy, seen in foundational models such as GraphDTA 141 , is to pair a GNN (which encodes the drug graph) with a CNN (which encodes the proteins amino acid sequence)

The people who experience them are nearly always making the same mistake: too much, too soon

Whereas the total glutathione (GSH+GSSG) concentrations in the epithelial lining fluid of healthy adult controls were similar to other published reference values (436 M ) (46, 233), these concentrations were reduced by more than threefold in children with severe asthma (129134 M ) (88)

Glutathionylation is known to play an important role in regulating the activity of NF-B and IB [52], and glutathionylation of IKK modulates the LPS-induced release of cytokines [53]

In addition, a pie chart displays the chemical class of changed metabolites in the ove-ECM1-MenSC treated group and ECM1-KD-MenSC treated group compared to the MenSC only treated group (Fig