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Now, in regards to the failed sphincter function after different NSAIDs, and later, to the improved sphincter function and smooth muscle function when BPC 157 was given, BPC 157, as a particular anti-ulcer pentadecapeptide, LD1 could be not achieved, effective alone without carrier (1-7) may be a suitable peptide candidate to additionally rescue such extended NSAIDs toxicity (1-14)

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12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones