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IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

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Theories include alteration of bile acid metabolism, small intestinal bacterial overgrowth, effects on intestinal motility and interference by metformin on vitamin B12-intrinsic factor absorption in the terminal ileum

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Vitamin B12 injection should be administered only under the recommendation and guidance of a medical professional and they should be aware of complete medical history including any conditions such as hypokalemia, polycythemia vera, gout, Lebers disease, iron and/or folic acid deficiency