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These motifs contain conserved amino acid residues that are critical for catalyzing RNA synthesis

Srimanee A, Regberg J, Hallbrink M, Kurrikoff K, Veiman K-L, Vajragupta O, et al

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Metformin is recommended as the first-line treatment for type 2 DM, as it can improve endothelial dysfunction by enhancing endothelium-dependent vasodilation and reducing sympathetic overactivity, ultimately restoring erectile responses in the CC of DM animal models through the NO/cGMP pathway [168]

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Therefore, although numerous small molecule drugs have been discovered for inducing and inhibiting ferroptosis, these drugs have not yet been translated into clinical applications to benefit patients