glutathione s-transferase 1 transferases as mediators of signaling pathways involved in cell proliferation and cell death Microsomal Glutathione S Human Glutathione S-transferase omega-1 (GSTO1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Barbey F., Lidove O., Dormond O

Phospholipid synthesis and remodeling in innate immunity PL synthesis and remodeling are mainly dependent on three interconnected enzyme pathways, including the Kennedy pathway (for PC, PE synthesis), the CDP-DAG (cytidine diphosphate-diacylglycerol) pathway (for PS, PI and CL synthesis) and the Lands cycle pathway (remodeling pathway, for the reversible removal and reattachment of fatty acids (FAs) to PLs) (Fig

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These enzymes can deploy Ni 2+ as a Lewis acid (electrophilic center), as seen in urease and glyoxalase I, or use redox chemistry as seen in NiSOD, Ni-Fe hydrogenase and CO dehydrogenase (Maroney & Ciurli, 2014)

In conclusion, this study demonstrates that both human and murine plasma exosomal cargo, specifically CYP2E1, play a role in exacerbating ALC- and APAP-induced toxicity in hepatocytes and monocytes