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FSEN1 was identified as a small-molecule inhibitor of FSP1 through chemical screening 118 , and subsequent structural analyses revealed that FSEN1 occupies the substrate-binding pocket of FSP1 in a position analogous to CoQ observed in the enzyme active site, providing structural insight into inhibitor recognition 119

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Functional assessments such as creatine loading tests and advanced tissue imaging (e.g., magnetic resonance spectroscopy) may offer dynamic, patient-specific evaluations of mitochondrial responsiveness and guide individualized preventive protocols