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In diabetes, when protective stimuli such as acetylcholine [162] and insulin [163] are diminished, there is a decrease in eNOS activity and expression, as well as eNOS uncoupling

by physically binding to globular actin (G-actin), the peptide prevents premature polymerization into filamentous actin (F-actin), thereby maintaining a pool of ready-to-use actin monomers

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Lower lipid levels benefit liver function and support cardiovascular health, addressing dyslipidemia, a common concern in NAFLD patients

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Through the summary of previous knowledge and recent updates, this review aims to provide a systematic understanding of TGF- signaling and to attract more attention and interest to this research area