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Although this trial did not demonstrate significant improvements in lung function, and the concomitant use of prednisone and azathioprine in that treatment arm actually worsened outcomes, N -acetylcysteine and other thiol-based antioxidants remain of interest as strategies to replenish intracellular glutathione in diseases such as COPD or cystic fibrosis, where they may mitigate oxidant-mediated macrophage dysfunction