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This indicates that tumor size does not determine necrosis development, and this is consistent with clinical observations that small GBMs can also develop necrosis 11

Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P

The result is a GH spike 23 higher than the endogenous pulse alone

Biomedicine & Pharmacotherapy, 57 (34), 145155

Supporting this EMT-promoting role, HGF-induced ROS oxidize the chaperone proteins HSP60 and PDI, thereby activating ERK and enhancing wound-healing and transwell migration