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In addition, Mdm2-mediated ubiquitination regulates FOXO transcriptional activity

Promoting Conversion (The Shift): The second, and perhaps most important, action is that Glutathione promotes the conversion of Eumelanin (the darker pigment) into Pheomelanin (the lighter pigment) By both reducing the total amount of pigment being made and shifting the pigment type toward the lighter version, Glutathione achieves its skin-lightening effect

Psychiatry 45, 743749

Then we optimized the enzymes structure through a method called protein engineering so that it efficiently converts precursor to 3MH, without generating off-target sulfur compounds

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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Garca-Bueno B., Caso J.R., Leza J.C