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These compounds are potent respiratory complex I inhibitors in isolated mitochondrial preparations (Li and Dryhurst, 1997, Li et al., 1998, Shen et al., 2000)

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Treatment with low concentrations of NaHS (10-100 M) increases the protein levels of phosphorylated-epidermal growth factor receptor (p-EGFR), phosphorylated-extracellular signal-regulated protein kinases (p-ERK), matrix metalloproteinase 2 (MMP-2), and p-Akt, which could activate the EGFR and its downstream signaling pathways to promote HCC proliferation and invasion (Fig

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Researchers frequently investigate glutathione because of its relationship to oxidative stress management and cellular protection mechanisms that may influence skin appearance and overall skin health