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Under physiological conditions, ROS levels are tightly regulated by endogenous antioxidant systems, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) (Li et al., 2025)

Curr Opin Hematol 9(4):294-302, 2002

Higher doses may not necessarily yield better results and could potentially increase side effects

Vitamin B12 is required for the metabolism of proteins and carbohydrates

Therefore, the severe interstitial edema, more expressed in white than in gray mater, and severe neuron loss in hippocampal neurons, neurons of dentate nucleus, Purkinje cells and other cerebellar nuclei and less severe damage in the pons, the mesencephalon and lateral geniculate body could be a specific paracetamol effect and these territories could be involved in the occurrence of maximal paracetamol induced seizures

Moreover, the combination of nanomaterials and hydrogels with plant bioactive metabolites further enhances the therapeutic effect, suggesting that PCs hold great promise for the treatment of DFU