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(PubMed) Bonvicini M, Travaglini S, Lelli D, Antonelli Incalzi R, Pedone C

In addition, serum iron levels are associated with an increased risk of IS and a lousy outcome (79, 85)

In patients with moderate or severe liver injury, prednisolone should be administered with discontinuation of the causative drug

2 Ferroptosis and its link to DCM Ferroptosis is a form of programmed cell death driven by the excessive accumulation of iron ions within cells, triggering the Fenton reaction, activating oxidative stress, and disrupting lipid metabolism, ultimately leading to cellular demise ( Acyl-CoA synthetase long-chain family member 4 (ACSL4) is a key enzyme involved in the synthesis of polyunsaturated fatty acid phosphatidylethanolamine (PUFA-PE) ( In patients with DCM, the GSH-dependent antioxidant mechanism is suppressed, whereas ACSL4 activation promotes ferroptosis in myocardial cells ( In the development of DCM, sustained hyperglycemia acts as a key driver of ferroptosis

106 This decreases hepatic glucose production and reduces hyperglycemia

30 , 13331339 (2006) Prabhakar, R., Vreven, T., Morokuma, K., Musaev, D.G.: Elucidation of the mechanism of selenoprotein glutathione peroxidase (GP x )-catalyzed hydrogen peroxide reduction by two glutathione molecules: a density functional study