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Conversely, integrase strand transfer inhibitors (INSTIs) such as Dolutegravir and Raltegravir are generally considered to have the most favorable mitochondrial safety profile, with little evidence of direct mtDNA toxicity

However, the last step of AsA synthesis is linked with a mitochondrial-localized enzyme called l-GalL dehydrogenase (l-GalLDH, EC 1.3.2.3) (Wheeler et al., 2015)

Statistical analysis Mean SEM was used to express all the data

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Research has shown that MT1G plays a crucial role as a tumor suppressor in pancreatic cancer stem cells

However, the output of an MCDA is highly sensitive to these weighting factors, which can be subjective