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Immune microenvironment dysregulation: a contributing factor to obesity-associated male infertility

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Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition

114 , 115 Relevant reports revealing haemosiderosis in patients undergoing dialysis resulted in reinvestigation of iron overload risks in CKD patients suffering from ESRD and inflammatory bowel disease (IBD), as a response to iron supplements authorised for marketing

Th1 cells drive cellular immunity and released pro-inflammatory cytokines such as IFN-, IL-1, IL-12, and TNF- [17]

As a result, targeting a single metabolic pathway may not lead to sustained therapeutic responses, as compensatory mechanisms can activate other pathways, undermining the treatments efficacy