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53 (ii) inhibition is reversible

Targeting tumors that lack Methylthioadenosine phosphorylase (MTAP) activity: current strategies

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The most notable reductions occurred in L-serine, while other groups showed decreases in L-leucine, N-acetylaspartylglutamate, N-methyl-L-glutamic acid, saccharopine, N-acetyl-alpha-D-glucosamine, N-acetylleucine, L-glutamine, L-arogenate, N-a-acetylcitrulline, 2-amino-2-deoxy-D-gluconate, pyroglutamic acid, L-leucine, gamma-glutamyltyramine, predominantly comprising serine, leucine, glutamic acid, and their derivatives

[179] demonstrated that elevated systemic iron levels trigger arterial iron deposition via NTBI, further inducing vascular dysfunction and plaque formation

Enzymatic antioxidants such as superoxide dismutase (SOD), catalase, and glutathione peroxidase play critical roles in neutralizing ROS [40]