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Kong L, Zhao Q, Jiang X et al (2024) Trimethylamine N-oxide impairs beta-cell function and glucose tolerance

Nature 2021, 599:136140

1.4.3 Limitations of benign and VUS classifications Ultimately, WES is not a genetic oracle, and in contrast to Mendelian diseases which often result from single-gene coding variants (Botstein and Risch, 2003), several complex traits could be driven by noncoding variants that presumably affect gene regulation