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as excess energy accumulates, white adipose tissue (WAT) cells undergo abnormal, hypertrophic growth, leading to poor blood supply (hypoxia), macrophage infiltration, and systemic inflammation

[DOI] [PMC free article] [PubMed] [Google Scholar] [116].Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC, VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase, FASEB J

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However, cardiac-specific Grk2 expression attenuates Ang II-induced increase in contractility and blood pressure [32], consistent with the pro- and anti-hypertensive effects of GRK2 that are tissue-dependent