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In studies of liposomal GSH, by 4 weeks they already saw increases in glutathione

Validated secondary biomarkers (e.g., Prostate Health Index, 4Kscore, IsoPSA [isoform PSA], Stockholm3, Proclarix, PCA3 [prostate cancer gene 3], SelectMDx [select molecular diagnostics], ExoDx [exosome diagnostics], MPS/MPS2 [MyProstateScore/MyProstateScore 2.0]) are best used selectively when MRI is negative or equivocal and clinical risk remains uncertain

Given this vital role, therapeutic strategies targeting TGF-1 and its downstream effectors are of high clinical relevance

Levites, Y., Amit, T., Mandel, S

doi: 10.1016/j.jbc.2023.105247 84 YokomizoTNakamuraMShimizuT

CCL2/MCP-1 Signaling Drives Extracellular Matrix Turnover by Diverse Macrophage Subsets