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High-glucose induces retinal pigment epithelium mitochondrial pathways of apoptosis and inhibits mitophagy by regulating ROS/PINK1/Parkin signal pathway

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KEAP1, which promotes the ubiquitination and subsequent degradation of NRF2, a key regulator of the antioxidant response, was upregulated in chemotherapy-sensitive tumors, suggesting that targeting the NRF2KEAP1 pathway could enhance the sensitivity of MIBC cells to cisplatin

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