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The major challenge in developing FKBP51-targeting drugs lies in the selectivity toward its homolog, FKBP52, which has similar binding pockets but has an opposite biological function

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Low-strength at-home exfoliating products can support maintenance, but they are not equivalent to a professional peel and carry real risk when misused on acne-prone or darker skin, including burns and post-inflammatory hyperpigmentation

Random forests

As observed in other organ models, most reported kidney-on-chip studies still rely on immortalized cell lines (176180), although recent work has increasingly explored patient-derived primary cells, spheroids, and organoids to establish autologous renal chips (166, 181185)