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Experiments performed in differentiated SH-SY5Y neuroblastoma cells have shown that exposure to PS-NPs downregulates expression of the CI subunit NDUFB8, leading to diminished basal and maximal oxygen consumption rates alongside increased proton leakagefurther confirming mitochondrial CI dysfunction 32

MOTS-c enhances how cells use energy

Hu, J, Yang, Q, Zhang, W, Du, H, Chen, Y, Zhao, Q, Dao, L, Xia, X, Fowlkes, NW, Zhang, Z, Mahadeo, KM, Gorlick, R, Kopetz, S , Dotti, G, Li, S

Low stomach acid can contribute to low iron levels and anemia by affecting nutrient absorption, as stomach acid is needed to extract iron and vitamin B12 from our protein-containing foods

p-value is derived from the two-sided Wilcoxon rank-sum test

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