Regulation of mitochondrial homeostasis by mTORC1 and mTORC2 Both mTORC1 and mTORC2 are essential for mitochondrial biogenesis, dynamics, the phosphorylation of mitochondrial proteins, mitochondrial genome repair, the cellular response to mitochondrial ROS, and the regulation of mitophagy
Research by GPS has the potential to enhance the expression of pro-apoptotic proteins, including Bax, which is a critical metabolite of the Bcl-2 protein family
Department of Ayush: Government of India
Saline soil conditions, on the other hand, can cause osmotic stress that in turn can inhibit cell expansion and cell division, impact stomatal closure, induce cell turgor via lowering water potential, and alter the normal homeostasis of cells (Miller et al., 2 O 2 , O 2 ) are common in plants exposed to high levels of salinity and/or metals (Benavides et al., Diverse plant taxa have been reported to adapt metabolically to salinity and exposure to metals by enhancing synthesis of sulfur (S)-rich peptides (such as glutathione, GSH) and low-molecular-weight nitrogenous and proteogenic amino acids/osmolytes (such as proline, Pro) (Khan et al., 2012
(XLSX 58 kb) Supplementary Table 4 (download XLSX This Supplementary Table contains Ingenuity Pathway Analysis (IPA) "Upstream Regulators" results derived from analysis of BT474 parental and persister cell RNAseq data
the invention relates to a pharmaceutical composition, hereinafter pharmaceutical composition of the invention, comprising fingolimod, an analogue, metabolite or derivative thereof or a pharmaceutically acceptable salt, and one or more drugs selected from the group consisting of an antioxidant, an antioxidant targeted to mitochondria, a histone deacetylase inhibitor, an inhibitor of mitochondria transition pore opening, an anti-inflammatory drug, a PPAR agonist, a RXR agonist, a sirtuin 1 agonist, an hypolipidemic drug and an autophagy activator
