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Orphanet J Rare Dis 2010

These substitution or replacement medications are modelled off of the success of opioid maintenance therapies, such as methadone and buprenorphine, for opioid use disorders [11]

Although these findings do not exclude Prx-independent H 2 O 2 signaling mechanisms, they clearly show that Prxs act as sensitive and common transducers of H 2 O 2 -derived oxidizing equivalents in redox signaling [18,19]

The inhibition efficacy was 78% and 97%, respectively (160)

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