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Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway

Fondevila, C

In addition, ROS induces both the activation and synthesis of AP-1, a regulator of cell growth, proliferation, and apoptosis [138, 139] and transcription factors such as STAT3, HIF-1, and p53 [118, 140, 141]

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Interactions and precautions to think over Pregnant or nursing mothers should be careful since safety data remains limited

The over-expression of genes related to malate transporter and citrate consumption indicated that the consume of L-malate and citrate were associated with acid stress response, and may be as an alternative energy source to sugar metabolism, just as described by Margalef-Catal et al