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Radiation necrosis (RN) may occur from months to years following treatment, affecting a reported 324% of patients [13]

4.5 Copper Copper (Cu) plays two main roles: it promotes melanogenesis and provides physiological protection against oxidative stress by participating in the destruction of free radicals through the formation of superoxide dismutase, which catalyses the dismutation of reactive oxygen species to oxygen (O 2 ) or H 2 O 2

At the same time, smoking induces systemic and local oxidative stress, impairing mitochondrial integrity and disrupting estrogen synthesis by downregulating aromatase and steroidogenic transport proteins

Pernicious anemia An autoimmune condition where the body attacks the parietal cells in the stomach, destroying its ability to produce intrinsic factor

Melatonin is derived from serotonin, a neurotransmitter that originates from the amino acid tryptophan

The primary objective of ongoing therapeutic trials is to reverse this dysfunction (Deng et al