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Indeed, glycine supplementation has been reported to slow the growth of various implanted tumors in rodents, likely owing to an antiangiogenic impact on endothelial cells.72-74 However, this effect might modestly retard wound healing.73 The antiangiogenic effect of glycine may reflect the fact that activation of endothelial NADPH oxidase, which the hyperpolarizing action of glycine may oppose, is a key mediator of the signaling pathway whereby vascular endothelial growth factor and its Flk-1 receptor promote proliferation and migration of endothelial cells.75,76 Additionally, glycine acts directly on a human hepatocyte line, via glycine receptors, to inhibit expression of vascular endothelial growth factor

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Body mass index (BMI), derived by height and weight, fails to accurately represent body fat content or account for muscle mass, bone density, or race/sex

Potassium channels may also be involved in maintaining vascular tone

In the presence of iron ions, the Fenton reaction produces highly reactive hydroxyl radicals from H 2 O 2