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Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

Drug Discovery Today Technol

Many genetic loci and mutations have been determined that can facilitate PD (Spatola and Wider, 2014)

2012), where it was used as a control in our experiments

Some researchers believe that these substitutions confer increased potency, receptor interaction efficiency, and an extended period during which the peptide might remain active in a controlled research setting

Although modulating B-cell-driven inflammatory amplification may hold therapeutic value, current evidence is still insufficient to support B cells as a direct therapeutic target, especially given that most mechanistic data derive from murine models and their contribution to human disease remains uncertain