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First, it is an endogenous molecule: it circulates in human plasma at a concentration of roughly 200 ng/mL around age 20, declining to about 80 ng/mL by age 60, a fall that has been linked, at least associatively, to the general decline in tissue regenerative capacity with age

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However, excessive activation of autophagy may result in adverse effects, as the process also contributes to follicular atresia and granulosa cells death

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