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GSH exists in two interconvertible forms: the biologically active reduced form (GSH) and the oxidised disulfide form (GSSG), in which two GSH molecules are joined at their sulfur atoms

Therefore, future research should focus on creating a comprehensive framework that integrates mechanistic elucidation, target validation, and intervention optimization

Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells

Lugo JP, Saiyed ZM, Lane NE

In contrast, dietary antioxidants could hinder tumorigensis and prevent tumor recurrence after standard cancer therapy via an antioxidant mechanism

Clustering by subcellular localization suggests evolutionary specialization, with GPXs adapting to specific organelle functions to manage oxidative stress effectively ( Figure 8