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89 COMPARISON OF RECURRENCE PREDICTION MODELS AND IMBRAVE 050 CRITERIA TO SELECT PATIENTS FOR ADJUVANT IMMUNOTHERAPY AFTER CURATIVE RESECTION OF HEPATOCELLULAR CARCINOMA I-Cheng Lee 1,2 , Hao-Cyuan Chu 2 , Shinn-Ying Ho 2 , Gar-Yang Chau 3 , Ming-Chih Hou 1 and Yi-Hsiang Huang 1,2 , (1)Taipei Veterans General Hospital, (2)National Yang Ming Chiao Tung University, (3)Taipei Veterans General Hospital Department Surgery Background: The IMbrave 050 trial recently demonstrated positive results of the adjuvant atezolizumab plus bevacizumab therapy for hepatocellular carcinoma (HCC) patients at high-risk of recurrence after curative treatment

In a hypoxic and glucose-deprived TME, The metabolism of Gln is essential for tumor cells to survive and multiply ( Additionally, metabolomic analyses reveal low levels of Gln and elevated levels of glutamate in TNBC, suggesting that TNBC is more dependent on Gln and more sensitive to therapies targeting Gln breakdown compared to other breast cancer subtypes ( The role of Gln is critical in both the proliferation and metastasis of cancer cells

Scientific Background of FOXO4-DRI FOXO4 belongs to the FOXO family of transcription factors responsible for regulating cellular stress responses, metabolism, and survival signaling

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Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al