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in: PubMed | Google Scholar | 1 Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Additionally, this recent and sophisticated classification system considers that colon and rectal carcinomas may be infiltrated with numerous immune cells, namely macrophages and T lymphocytes, as well as fibroblasts, adipocytes, and endothelial cells, all of which form the complex CRC tumor microenvironment (TME)