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Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20

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For example, researchers have found that HRAS V 12 expressing cancer cells are electively sensitive to ferroptosis, and KRAS silencing in KRAS mutant Calu-1 cells strongly reduces erastin sensibility (Yagoda et al., 2007)

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Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors