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The impact of these biochemicals on human health is complex, as both potentially beneficial and potentially toxic metabolites can be yielded from such microbial pathways, and in some cases, these effects are dependent upon the metabolite concentration or organ locality

We review the scientific evidence related to these redox pathways, separately for SARS-CoV-2 versus all the other coronaviruses [SARS-CoV, MERS, respiratory coronaviruses and other coronaviruses used to model SARS-CoV-2 infection such as the murine hepatitis virus (MHV)]

10.1016/j.freeradbiomed.2004.06.011

Furthermore, apigenin appears to modulate neurotransmitter levels (dopamine, serotonin) (Nakazawa et al., 2003

Moreover, it plays an immune negative regulatory role in chronic hepatitis B virus (HBA) infection by preventing the formation of germinal centers (GCs), reducing the antiviral activity of GC-related immune cells and enhancing the function of immunosuppressive cells [227]

While mono is usually self-limiting and not severe , patients may develop secondary infections such as streptococcal pharyngitis, sinusitis, or bacterial tonsillitis, which may complicate the clinical picture