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M.Pereira Menezes ReisS.Peres GramachoK.MicheliF

Log 2 fold change shrinkage was applied using the lfcShrink function in DESeq2 with the apeglm method

Common autoimmune conditions include: Hashimotos thyroiditis, a thyroid gland autoimmune disorder and a type of hypothyroidism Lupus, a systemic autoimmune disease that can impact multiple organs Rheumatoid arthritis, an autoimmune arthritis marked by joint damage and pain Multiple sclerosis, an autoimmune attack on the nervous system itself Psoriasis and eczema, which affect the skin and can cause dryness, sensitivity, and redness Celiac disease, an allergy to gluten, which is found in grains like wheat and barley Crohn's disease, a type of inflammatory condition affecting the gut and digestive tract Endometriosis, which is not officially classified as an autoimmune disease, endometriosis but exhibits autoimmune and inflammatory characteristics

2 Introduction Non-steroidal anti-inflammatory drugs (NSAIDs) are a diverse group of drugs with analgesic, anti-inflammatory, and antipyretic (fever-reducing) properties

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The combination is widely used in research protocols studying pulsatile GH release patterns